Ora CAE® Dry Eye Challenge

Removes the noise from data

When study patients are exposed to Ora’s CAE® (Controlled Adverse Environment) Dry Eye Challenge in terms of relative humidity, temperature, airflow, and visual tasking, the ocular surface is stressed to react. This controlled environmental stress creates a consistent response that’s reproducible over time. Data derived from the CAE® model offers greater precision in predicting the efficacy of your drug – with fewer patients, fewer sites, and less time.

The Ora CAE®Dry Eye Challenge creates the ideal paradigm for identifying:

  1. An enriched population of dry eye patients with modifiable signs and symptoms
  2. Endpoints for intervention that show relevant change.

We provide a menu of trial designs within the context of CAE®: from traditional endpoints, to CAE® model patient screening and enrichment, to a full CAE® trial with screening/patient enrichment and CAE®-specific endpoints of dry eye disease. We work with you to determine the right approach for your product.

Our Mobile Dry Eye Units enable multi-center dry eye trials while still reducing clinical variables among sites. With Ora, you can bring your clinical trial to the patient.

The Ora CAE® Model can be:

  • Tailored to the MOA of the therapeutic to be tested
  • Used as an enrichment tool to identify and enroll the appropriate patient population for each study design
  • Relied on to provide endpoints that demonstrate change with interventions
  • Used at multiple sites across the globe